Historical Perspective HIGHLIGHTED TOPIC Neural Control of Movement Historical analysis of the neural control of movement from the bedrock of animal experimentation to human studies

Matthews, Peter B. C. Historical analysis of the neural control of movement from the bedrock of animal experimentation to human studies. J Appl Physiol 96: 1478–1485, 2004; 10.1152/japplphysiol.00978.2003.—The history of the investigation of the sensorimotor control of movement is outlined from its inception at the beginning of the 19th century. Particular emphasis is placed on the opening up of new possibilities by the development of new techniques, from chronophotography to magnetic brain stimulation, all of which have exploited developments in technology. Extrapolating from history, future advance in physiological understanding can be guaranteed to require seizing the new tools provided by the physical sciences and refining these to our particular need. The ever-present danger is that these are then deployed with triumphal optimism rather than critical doubt and earlier methods either jettisoned prematurely or used incautiously. The new techniques have enabled experimentation to become ever less intrusive, permitting a progressive shift from animal to human work, thereby offering the prospect of an increasing clinical reward.